Public release of code and analyses related to Multi-omics Factor Analysis (MOFA) using data from the Religious Orders Study (ROS) and Rush Memory and Aging Project (MAP) cohorts.
This repository accompanies the preprint:
Scheidemantel LP, de Paiva Lopes K, Gaiteri C, Menon V, De Jager PL, Schneider JA, Buchman AS, Wang Y, Tasaki S, Raittz RT, Bennett DA, Vialle RA.
Integration of aged brain multi-omics reveals cross-system mechanisms underlying Alzheimer’s disease heterogeneity.
bioRxiv (2025). doi: 10.1101/2025.09.23.678110
Key findings include:
1.MOFA_analysis/ – Core MOFA
implementation and factor extraction.2.GSEA_analysis/ – Gene Set Enrichment
Analysis of MOFA factors.3.Loadings_analysis/ – Examination of
omics loadings contributing to factors.4.Phenotypes_analysis/ – Associations
between MOFA factors and AD phenotypes.5.Clustering_analysis/ – Unsupervised
clustering of participants into molecular subtypes.6.Manuscript_code/ – Misc. scripts
used to generate other figures and results.Distributed under terms of the GNU GENERAL PUBLIC LICENSE.